Endocrine Abstracts

Introduction: Early prediction of anticancer therapy cardiotoxicity is essential for applying proper preventive and supporting therapeutic strategies.Objective: To evaluate plasma N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) related to cardiac dysfunction assessed by transthoracic 2D echocardiography (2D-TTE) in patients with cancer and early onset asymptomatic anthracycline-induced cardiomyopathy (AIC).Methods:...

Background: Risk stratification could be lifesaving in acute pulmonary embolism (PE). Echocardiographic (ECHO) acute right ventricular dysfunction (RVD) is the actual ‘gold standard’ in risk assessment of patients with PE. We previously demonstrated that plasma BNP levels were significantly higher in patients with PE and acute RVD on ECHO versus patients with normal right ventricular (RV) function on ECHO.Aim and objective: Evaluation of the li...

Introduction: The study aimed to analyze the efficiency of a concomitant N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac high-sensitivity troponin T (hs-cTnT) testing in diagnosing non-ST-segment-elevation myocardial infarction (NSTEMI) in patients initially negative for the standard fourth-generation assay of cardiac troponin T (cTnT), but with high clinical probability of non-ST-segment-elevation acute coronary syndrome (NSTE-ACS).Meth...

Background: We previously demonstrated plasma BNP to be a valuable biomarker of right ventricular dysfunction (RVD) in patients with acute pulmonary embolism (PE). Several specific ECG abnormalities related to the right ventricular strain were described in patients with PE.Objective: Assessment of the correlation of plasma BNP levels with ECG signs of RVD in patients with PE.Methods: Seventy patients with confirmed acute PE, 42(60%...

Introduction: Acute right ventricular dysfunction (RVD) on echocardiography (ECHO) represents the actual gold standard in risk stratification of patients with pulmonary embolism (PE). We previously demonstrated that plasma BNP above a cut-off level of 50 pg/ml could predict acute RVD in PE.Aim and objective: Analysis of the utility and accuracy of plasma BNP in detecting acute RVD in PE.Methods: Seventy patients with confirmed PE, ...

Introduction: Atheromatous plaque instability biomarkers are the most important predictors for the evolution with major acute cardiovascular events (MACE) in patients with NSTE-ACS.Objective: To evaluate the impact of dyslipidemia, endothelial dysfunction, oxidative stress, platelet hyperactivity and hypercoagulable state and their inter-correlation on the outcome of NSTE-ACS.Methods: Two hundred and forty patients with NSTE-ACS, 1...